What is
"Clinical-Grade"?
It's simple. We don't compromise on efficacy
The beauty actives in ION™ are intentionally blended for your beauty, using +100% dosages verified through human clinical trials.
Now, all that’s left is your consistency.
* Green bars on the graph is the content of each ingredient in ION™
* Others : Gummy, Liquid, Powder with beauty claims
Over 30 years of research by 130+ scientists support ION-01™'s ingredients.
Collagen Peptides
Reilly DM, Kynaston L, Naseem S, Proudman E, Laceby D. Improvement in skin collagen, hydration, elasticity, wrinkles, scalp, and hair after 12-week oral hydrolysed collagen intake. Dermatol Res Pract. 2024;2024:8752787. doi:10.1155/2024/8752787. PMID:39021368.
Choi SY, Ko EJ, Lee YH, et al. Effects of oral collagen for skin anti-aging: A systematic review and meta-analysis. Nutrients. 2023;15(14):3104. doi:10.3390/nu15143104. PMID:37432180. PMCID:PMC10180699.
Hexsel D, Zague V, Schunemann E, et al. Bioactive collagen peptides improve nail growth and brittle nail symptoms. J Cosmet Dermatol. 2017;16(4):520–526. doi:10.1111/jocd.12393. PMID:28786550.
Bolke L, Schlippe G, Gerß J, Voss W. Oral collagen peptides improve skin hydration, elasticity, roughness, and density. Nutrients. 2021;13(7):2314. doi:10.3390/nu13072314. PMID:33774639.
Asserin J, Lati E, Shioya T, Prawitt J. Oral collagen peptides improve skin moisture and dermal collagen network. J Cosmet Dermatol. 2015;14(4):291–301. doi:10.1111/jocd.12174. PMCID:PMC11254459.
Inoue N, Sugihara F, Wang X. Enzymatically decomposed collagen peptides improve skin moisture and elasticity. Nutrients. 2021;13(2):550. doi:10.3390/nu13020550.
Glutathione
Allen J, Bradley RD. Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2014;53(1):251–263. doi:10.1007/s00394-013-0538-x. PMID:24791752.
Weschawalit S, Phutrakool P, Chanprapaph K, Rojhirunsakool S. Glutathione and its anti-aging and antimelanogenic effects. Clin Cosmet Investig Dermatol. 2017;10:147–153. PMCID:PMC5413479.
Arjinpathana N, Asawanonda P. Glutathione as an oral whitening agent: A randomized, double-blind, placebo-controlled study. J Dermatol Treat. 2010;21(6):359–363. doi:10.3109/09546630903505440. PMID:20524875.
Dilokthornsakul P, et al. Systematic clinical summary of oral glutathione trials. J Dermatolog Treat. 2019;30(6):1–8. PMID:30895708.
(Glucosyl)ceramides
Sugino H, Nakagawa K, Deguchi Y, et al. Oral glucosylceramide intake improves transepidermal water loss. J Oleo Sci. 2013;62(12):893–904. doi:10.5650/jos.ess13163.
Maeda A, Watanabe T, Okamoto T, et al. Safety and efficacy of ceramide-containing acetic acid bacteria in healthy adults. Eur J Nutr. 2020;59(6):2811–2821. doi:10.1007/s00394-019-02154-x. PMID:33055441.
Choi SY, Kim SE, Kang D, et al. Oral wheat glucosylceramides improve skin hydration. Cosmetics. 2017;4(4):40. doi:10.3390/cosmetics4040040.
Astaxanthin
Tominaga K, Hongo N, Karato M, Yamashita E. Cosmetic benefits of astaxanthin on human subjects. Acta Biochim Pol. 2012;59(1):43–47. doi:10.18388/abp.2012_2168. PMID:22428137.
Zhou X, Cao Q, Orfila C, Zhao J, Zhang L. Systematic review and meta-analysis on astaxanthin and skin ageing. Nutrients. 2021;13(9):2917. doi:10.3390/nu13092917. PMCID:PMC8472736.
Park H, Lee HJ. Astaxanthin in skin health, repair, and disease. Antioxidants (Basel). 2018;7(2):34. PMCID:PMC5946307.
Probiotics / Postbiotics
Kang S, Park MY, Brooks I, et al. Bacillus coagulans SNZ 1969 improves intestinal motility and constipation perception. Food Res Int. 2021;146:110428. doi:10.1016/j.foodres.2021.110428. PMID:34119240.
Morita H, He F, Fuse T, et al. Heat-killed L. casei 327 improves defecation frequency. Biosci Microbiota Food Health. 2018;37(1):1–9. PMCID:PMC6081609.
Sugawara T, Sawada D, Ishida Y, et al. Heat-killed L. casei 327 improves skin condition by reducing TEWL. Nutrients. 2017;9(8):803. PMCID:PMC5510156.
Hair Oils & Lipids
Cho YH, Lee SY, Jeong DW, et al. Pumpkin seed oil improves hair growth in androgenetic alopecia. Evid Based Complement Alternat Med. 2014;2014:549721. doi:10.1155/2014/549721. PMID:24864154. PMCID:PMC4017725.
Beoy LA, Woei WJ, Hay YK. Tocotrienol supplementation and hair growth. Trop Life Sci Res. 2010;21(2):91–99. PMID:24575202. PMCID:PMC3819075.
Chung BY, Park SY, Jung MJ, et al. Evening primrose oil in mild atopic dermatitis. Ann Dermatol. 2018;30(4):409–416. doi:10.5021/ad.2018.30.4.409. PMID:30065580. PMCID:PMC6029968.
Biotin
Nazaruk J, Mielczarek-Puta M. Treatment of brittle fingernails and onychoschizia with biotin. Dermatologica. 1990;180(6):238–241. PMID:2273113.
Wetter DA, Davis MDP. Brittle nails: response to daily biotin supplementation. J Am Acad Dermatol. 1993;28(3):433–436. PMID:8477615.
Pawlowski A, Kostanecki W. Effect of biotin on hair roots and sebum excretion in women with diffuse alopecia. Pol Med J. 1966;5(2):447–452. PMID:4223823.
Şen O, Türkçapar AG. Hair loss after sleeve gastrectomy and effect of biotin supplements. J Laparoendosc Adv Surg Tech A. 2021;31(3):296–300. doi:10.1089/lap.2020.0468. PMID:32762597.
Zinc
Verma KC, Saini AS, Dhamija SK. Oral zinc sulphate therapy in acne vulgaris. Acta Derm Venereol. 1980;60(4):337–340. doi:10.2340/0001555560337340. PMID:6163281.
Sharquie KE, Najim RA, Al-Salman HN. Oral zinc sulfate in rosacea. Int J Dermatol. 2006;45(7):857–861. doi:10.1111/j.1365-4632.2006.02944.x. PMID:16863527.
Myo-Inositol
Zacchè MM, Caputo A, Ferraretto A, et al. Myo-inositol in dermatological disorders in PCOS. Eur J Obstet Gynecol Reprod Biol. 2009;144(1):51–54. PMID:19551544.
Pezza M, Carlomagno V, Sammarco E, et al. Myo-inositol with magnesium in androgen-dependent dermatological diseases. Pharmaceuticals. 2025;18(2):251. doi:10.3390/ph18020251. PMCID:PMC11859446.
Galacto-Oligosaccharides (GOS)
Matsumoto K, Mizukoshi T, Takahashi Y, et al. Dietary galacto-oligosaccharides improve skin health: A randomized, double-blind clinical trial. Nutrition. 2017;33:1–6. doi:10.1016/j.nut.2016.06.023. PMID:28582809.
Lutein & Zeaxanthin
Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers. Clin Cosmet Investig Dermatol. 2016;9:325–332. doi:10.2147/CCID.S115519. PMID:27785083. PMCID:PMC5063591.
Partially Hydrolyzed Guar Gum (PHGG)
Edelman M, Wang Q, Ahnen R, Slavin J. The dose-response effects of partially hydrolyzed guar gum on gut microbiome of healthy adults. Appl Microbiol. 2024;4(2):720–730. doi:10.3390/applmicrobiol4020049.
Vitamin C
Pullar JM, Bozonet SM, Segger D, et al. Improved human skin vitamin C levels and skin function after dietary intake of kiwifruit. J Invest Dermatol. 2025;145(11). doi:10.1016/j.jid.2025.10.587. PMID:41167549.
MSM (Methylsulfonylmethane)
Muizzuddin N, Benjamin R. Beauty from within: Oral methylsulfonylmethane improves signs of skin ageing. Int J Vitam Nutr Res. 2022;92(3-4):182–191. doi:10.1024/0300-9831/a000643. PMID:32083522.
Hyaluronic Acid
Hsu TF, Su ZR, Hsieh YH, et al. Oral hyaluronan relieves wrinkles and improves dry skin. Nutrients. 2021;13(7):2220. doi:10.3390/nu13072220. PMID:34203487. PMCID:PMC8308347.
ch-OSA (Silicon)
Tetzlaff JE, Jacob S, Marsh C, et al. Oral ch-OSA improves skin, hair, and nails in photo-aged women. Arch Dermatol Res. 2007;298(10):487–498. doi:10.1007/s00403-007-0788-z. PMID:16205932.
Coenzyme Q10
Žmitek K, Pogačnik T, Mervic L, et al. Dietary coenzyme Q10 improves skin parameters. Biofactors. 2017;43(1):132–140. doi:10.1002/biof.1316. PMID:27548886.